iLEADS Active Study Page

Welcome to the International branch of the LEADS study.

This section encompasses study specific tools and videos for your reference. If you have any questions, comments, or new ideas please contact NCRAD by email or phone 1-800-526-2839 or directly at 317-278-8413.

CI (Cognitively Impaired) Participants

**Please note that this EDTA tube is used for the purpose of confirmation testing and is only drawn during the Baseline visit for CI participants.
	Baseline	M12	M24	M36	M48/Annual Visit
Serum
Plasma
Buffy Coat (DNA)
Whole Blood for CLIA lab testing
Whole Blood for Long Read Sequencing		Collected only once over the entire course of a participant's participation in the iLEADS Study. May be collected at longitudinal visits if not collected at Baseline"
Whole Blood for RNA
Whole Blood for PBMC * optional
CSF *optional

**Please note that this EDTA tube is used for the purpose of confirmation testing and is only drawn during the Baseline visit for CI participants.

CN (Cognitively Normal) Participants

** Please note that CSF is to be drawn at Baseline and M24 for CN participants. Can be drawn at M12 if not drawn at Baseline.
	Baseline	M12	M24	M36	M48/Annual Visit
Serum
Plasma
Buffy Coat (DNA)
Whole Blood for CLIA lab testing
Whole Blood for Long Read Sequencing		Collected only once over the entire course of a participant's participation in the iLEADS Study. May be collected at longitudinal visits if not collected at Baseline"
Whole Blood for RNA
Whole Blood for PBMC * optional
CSF *optional

** Please note that CSF is to be drawn at Baseline and M24 for CN participants. Can be drawn at M12 if not drawn at Baseline.

Study Resources

Kit Request Module

Please follow the below link to access the Kit Request Module. This link will direct you to a REDCap database where study coordinators and staff may request kits, individual supplies, and/or labels. Study related sites will use the same link for ordering supplies related to blood-based samples and for CSF. Please allow a total of three weeks for kit requests to be compiled and delivered to your site.

Kit Request System

Biological Sample and Shipment Notification Forms

Please use the below downloadable forms to collect information on specimen patient demographics, collection, and processing. We respectfully ask that all completed forms be emailed prior to shipment. If you complete the form on the website, you can choose to have it emailed automatically to us. We also ask that all shipments include a hard copy of each sample form.

Downloadable Blood Sample Form

Downloadable CSF Sample Form

manual of procedures

The below downloadable manual for biomarkers was created specifically for the study. Please feel free to explore the manuals through the hyperlinked “Table of Contents.” Questions concerning any part of the manual may be directed to NCRAD at (alzstudy@iu.edu, 1-800-526-2839 or directly at 317-278-8413) for further clarification.

Manual of Procedures

Training slides

Please see the link below for the training slides for the study.

Training Slides

Training Video

Sample Services at NCRAD

Looking for a biorepository to bank your samples? Check out NCRAD for sample banking. We can bank samples for new studies, ongoing studies, and closed studies.

Bank samples at NCRAD

Looking for samples for your research? Check out NCRAD’s inventory of available samples. Our Biomarker Analysis Laboratory (BAL) provide insights through standardized processing and cross-laboratory comparability studies.

Access samples at NCRAD Learn more about BAL