Researchers seeking to identify the genes contributing to the risk for Alzheimer's disease and other related diseases may be limited in their attempts to obtain large, well-characterized families with Alzheimer's disease (AD). The National Cell Repository for Alzheimer's Disease (NCRAD) was established to provide the research community with DNA and cell lines from large numbers of informative families with multiple individuals affected with Alzheimer's Disease or related diseases. NCRAD samples are available for qualified researchers who are interested in expanding the understanding of the etiology, pathogenesis, diagnosis, treatment and prevention of diseases like AD.

Please Note: NCRAD has developed a new cost recovery plan that will assist us in distributing large numbers of samples to more researchers. Detailed information about this cost recovery plan is available for download. And ADNI fee schedule is also available.

The following information is collected and maintained for each family participating in NCRAD:

• Family history
• Demographic data
• Medical records on the evaluation, diagnosis, and treatment of symptomatic subjects
• Neuropathological findings, when available

Procedure for requesting NCRAD samples
Requests for cell cultures and/or DNA samples must be submitted in the form of a brief written proposal, outlining the intended use of the samples. Proposals should include the following:

• A description of the research project
• The type (affected vs unaffected persons, early vs late onset, etc) and number of samples being requested. The Repository reserves the right to limit the number of samples provided per request.
• Name of the Principal Investigator and any other investigators who will be using the samples
• If applicable, the number of the grant or contract which supports the research

Phone calls requesting information about the project or available samples are welcome. If project is approved, a Material Transfer Agreement will need to be signed prior to shipment of samples. The Material Transfer Agreement states that researchers may not transfer cells or DNA to a third party.

Please view and use the following forms for more information on the Material Transfer Agreement:

• Requesting Materials From NCRAD (.pdf document)
• Sending Materials To NCRAD (.pdf document)
• Revised NIA Sharing Plan (.pdf document)

To view .pdf documents, you will need Adobe Acrobat Reader.

Please submit proposals to:

Tatiana Foroud, Ph.D.
Hereditary Genomics
Health Information and Translational Sciences Building - HS 4000
410 West 10th Street
Indianapolis, IN 46202-3002
Phone: 800-526-2839 or 317-274-7360
FAX: 317-274-2387

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