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The National Cell Repository for Alzheimer's Disease (NCRAD) is
a resource facility funded by the National Institute on Aging. The
purpose of the Repository is to provide important and critical resources
to assist researchers in identifying the genetic factors (genes)
contributing to Alzheimer’s disease and other types of dementia.
To perform these important studies, scientists require genetic material
(DNA) from individuals and families having multiple members diagnosed
with Alzheimer’s disease or other types of dementia. Learn
more about the genetics of Alzheimer's Disease.
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The National Cell Repository for Alzheimer's Disease is housed at
Indiana University Medical Center in Indianapolis, Indiana. Even
though we are located in Indiana, we work with families nationwide.
It is not necessary for study participants to come to Indiana.
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We are looking for families with two or more blood related individuals
who may be affected with memory loss or Alzheimer’s Disease
(AD) and who are still living.
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- Provide Family History Information. As part of a family’s
participation in this study, you may be asked to provide family
history information. You also may be contacted periodically for
additional or updated family information.
- Provide a Blood Sample. The blood samples that we request
are not used to test for a diagnosis of AD. These samples are
used to obtain the genetic material, called DNA, that is used
for research.
- Provide Documentation of Clinical History. Family members
may be asked to sign medical release so that we can obtain documentation
of serious memory loss or AD in the family. Some members may be
asked to undergo physical and/or neurological examinations. These
examinations may be performed in a clinical research center or
an Alzheimer’s disease researcher may come to see the family
member.
- Plan an Autopsy for Yourself or a Loved One. One other
way that we can learn more about AD is through the careful examination
of brain tissue of family members who have been diagnosed with
AD. We can work with families to arrange an autopsy plan and we
will help cover the costs associated with the autopsy.
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In order to identify the genes important in predicting who is likely
to develop Alzheimer’s disease, researchers must perform genetic
studies using DNA from individuals who have and have not developed
Alzheimer’s disease. It can be extremely costly and time consuming
to identify individuals and families with multiple members diagnosed
with Alzheimer’s disease. To help researchers more rapidly
unravel the mystery of Alzheimer’s disease, the NIA is working
with 29 Alzheimer’s Disease Research Centers to identify 1,000
families with 2 or more living brothers or sisters diagnosed with
Alzheimer’s disease.
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Participation in the National Institute on Aging Alzheimer’s
Disease Family Studies are totally voluntary. All individuals
participating in the National Institute on Aging genetic studies
must sign an Informed Consent form that gives permission for each
individual to participate in this project. Family members are free
to decline or discontinue participation at any time. There should
be no cost to take part in the study. All information you provide
will be kept confidential.
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To learn more about the National Cell Repository for Alzheimer Disease,
please contact us by email at alzstudy@iupui.edu,
by telephone (Toll Free) at 1-800-526-2839 or by writing to us at
the address below.
National Cell Repository for Alzheimer’s Disease (NCRAD)
Division of Hereditary Genomics
Health Information and Translational Sciences Building
410 West 10th Street, HS 4000
Indianapolis, IN 46202-3002
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